About
Medicine Changes Lives.
Research Changes the World.
Massachusetts General Hospital is home to the largest hospital-based research enterprise in the U.S., with an annual budget of $1 billion in 2019. The Mass General Research Institute comprises more than 8,500 researchers working across more than 30 institutes, centers and departments.
As the oldest and largest teaching hospital of Harvard Medical School, Mass General has been a leader in bridging innovative science with highly advanced clinical care for more than 200 years.
Bulfinch building circa 1937-1938

Transforming Medicine Through Innovation
The Research Institute is built on a culture of excellence, compassion and groundbreaking scientific achievement. Our researchers work side-by-side with physicians harnessing the latest technological advancements to foster discovery at every stage.
Among the medical and scientific “firsts” at Mass General are the first demonstration of ether as a general anesthetic, the first x-ray exposure produced in a hospital, the first antiseptic operating suite in the U.S., and the invention of MRI and fMRI imaging technologies.