Effect of Screening for Undiagnosed Atrial Fibrillation on Stroke Prevention
Lopes RD, Atlas SJ, Go AS, Lubitz SA, McManus DD [et al.], Singer DE
Published in Journal of the American College of Cardiology on 8/29/2024

Rare coding variant analysis for human diseases across biobanks and ancestries
Jurgens SJ, Wang X, Choi SH, Weng LC, Koyama S [et al.], Ellinor PT
Published in Nature Genetics on 8/29/2024

Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment
Shiau C, Cao J, Gong D, Gregory MT, Caldwell NJ [et al.], Hwang WL
Published in Nature Genetics on 9/3/2024

Combination Targeted Therapy with Pembrolizumab and Lenvatinib in Progressive, Radioiodine-Refractory Differentiated Thyroid Cancers
French JD, Haugen BR, Worden FP, Bowles DW, Gianoukakis AG [et al.], Wirth LJ
Published in Clincal Cancer Research on 9/3/2024

Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling
El Zarif T, Meador CB, Qiu X, Seo JH, Davidsohn MP [et al.], Berchuck JE
Published in Clincal Cancer Research on 9/3/2024

A γδ T cell-IL-3 axis controls allergic responses through sensory neurons
Flayer CH, Kernin IJ, Matatia PR, Zeng X, Yarmolinsky DA [et al.], Sokol CL
Published in Nature on 9/4/2024 | Press Release

Aficamten and Cardiopulmonary Exercise Test Performance: A Substudy of the SEQUOIA-HCM Randomized Clinical Trial
Lee MMY, Masri A, Nassif ME, Barriales-Villa R, Abraham TP [et al.], Lewis GD; SEQUOIA-HCM Investigators
Published in JAMA Cardiology on 9/4/2024

Racial, ethnic, and sex bias in large language model opioid recommendations for pain management
Young CC, Enichen E, Rao A, Succi MD
Published in Pain on 9/6/2024 | Press Release

Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis
Uddin MM, Saadatagah S, Niroula A, Yu B, Hornsby WE [et al.], Natarajan P
Published in Nature Communications on 9/9/2024

Serial Shock Severity Assessment Within 72 Hours After Diagnosis: A Cardiogenic Shock Working Group Report
Ton VK, Li S, John K, Li B, Zweck E [et al.], Kapur NK
Published in Journal of the American College of Cardiology on 9/10/2024

Reproducibility and Repeatability of US Shear-Wave and Transient Elastography in Nonalcoholic Fatty Liver Disease
Pierce TT, Ozturk A, Sherlock SP, Moura Cunha G, Wang X [et al.], Samir AE
Published in Radiology on 9/10/2024

Unraveling the Long-term Natural History of Branch Duct Intraductal Papillary Mucinous Neoplasm: Beyond 10 years
Assawasirisin C, Fagenholz P, Qadan M, Hernandez-Barco Y, Aimprasittichai S [et al.], Fernández-Del Castillo C
Published in Annals of Surgery on 9/10/2024

Telehealth vs In-Person Early Palliative Care for Patients With Advanced Lung Cancer: A Multisite Randomized Clinical Trial
Greer JA, Temel JS, El-Jawahri A, Rinaldi S [et al.], Jackson V; REACH PC Investigators
Published in JAMA on 9/11/2024 | Research Spotlight

Divorce Among Surgeons and Other Physicians in the United States
Stearns SA, Farid AR, Jena AB
Published in Annals of Surgery on 9/11/2024

Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial
Juelg B, Walker-Sperling VEK, Wagh K, Aid M, Stephenson KE [et al.], Barouch DH
Published in Nature Medicine on 9/12/2024

Nuclear lamin A/C phosphorylation by loss of androgen receptor leads to cancer-associated fibroblast activation
Ghosh S, Isma J, Ostano P, Mazzeo L, Toniolo A [et al.], Paolo Dotto G
Published in Nature Communications on 9/12/2024

Phase 1 study of CAR-37 T cells in patients with relapsed or refractory CD37+ lymphoid malignancies
Frigault MJ, Graham CE, Berger TR, Ritchey J, Horick NK [et al.], Maus MV
Published in Blood on 9/12/2024

HPV-YAP1 oncogenic alliance drives malignant transformation of fallopian tube epithelial cells
He C, Lv X, Liu J, Ruan J, Chen P [et al.], Wang C
Published in EMBO Reproduction on 9/13/2024

The bacterial quorum sensing signal 2'-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection
Chakraborty A, Bandyopadhaya A, Singh VK, Kovacic F, Cha S [et al.], Rahme LG
Published in eLife on 9/13/2024

Belzutifan for patients with von Hippel-Lindau disease-associated CNS haemangioblastomas (LITESPARK-004): a multicentre, single-arm, phase 2 study
Iliopoulos O, Iversen AB, Narayan V, Maughan BL, Beckermann KE [et al.], Jonasch E
Published in Lancet Oncology on 9/13/2024

Reaction Risk to Direct Penicillin Challenges: A Systematic Review and Meta-Analysis
Blumenthal KG, Smith LR, Mann JTS, Salciccioli I, Accarino JJO, Shah RJ, Alvi FI, Cardoso-Fernandes A, Ferreira-da-Silva R, Schunemann HJ, Sousa-Pinto B
Published in JAMA Internal Medicine on 9/16/2024 | Research Spotlight

Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
Weiss SA, Huang AY, Fung ME, Martinez D, Chen ACY [et al.], Sen DR
Published in Nature Immunology on 9/17/2024

County-Level Enrollment in Medicare Advantage Plans Offering Expanded Supplemental Benefits
Yang Z, Zhu E, Cheng D, Price M, Alegria M [et al.], Fung V
Published in JAMA Network Open on 9/17/2024

Commensal consortia decolonize Enterobacteriaceae via ecological control
Furuichi M, Kawaguchi T, Pust MM, Yasuma-Mitobe K, Plichta DR [et al.], Honda K
Published in Nature on 9/18/2024

Pomalidomide for Epistaxis in Hereditary Hemorrhagic Telangiectasia
Al-Samkari H, Kasthuri RS, Iyer VN, Pishko AM, Decker JE [et al.], McCrae KR
Published in New England Journal of Medicine on 9/18/2024 | Press Release

ARGX-119 is an agonist antibody for human MuSK that reverses disease relapse in a mouse model of congenital myasthenic syndrome
Vanhauwaert R, Oury J, Vankerckhoven B, Steyaert C, Jensen SM [et al.], Burden SJ
Published in Science Translational Medicine on 9/18/2024

Year-Long Cannabis Use for Medical Symptoms and Brain Activation During Cognitive Processes
Burdinski DCL, Kodibagkar A, Potter K, Schuster RM, Evins AE, Ghosh SS, Gilman JM
Published in JAMA Network Open on 9/18/2024

Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment
Zhu M, Frank MW, Radka CD, Jeanfavre S, Xu J [et al.], Kwon DS
Published in Cell on 9/19/2024

Perceived Chronic Traumatic Encephalopathy and Suicidality in Former Professional Football Players
Grashow R, Terry DP, Iverson GL, DiGregorio H, Dairi I [et al.], Baggish AL
Published in JAMA Neurology on 9/23/2024 | Press Release

Alzheimer Dementia Among Individuals With Down Syndrome
Rubenstein E, Tewolde S, Michals A, Weuve J, Fortea J [et al.], Skotko BG
Published in JAMA Network Open on 9/23/2024

A potential target for noninvasive neuromodulation of PTSD symptoms derived from focal brain lesions in veterans
Siddiqi SH, Philip NS, Palm ST, Carreon DM, Arulpragasam AR [et al.], Fox MD
Published in Nature Neuroscience on 9/24/2024

Monitoring surgical nociception using multisensor physiological models
Subramanian S, Tseng B, Del Carmen M, Goodman A, Dahl DM, Barbieri R, Brown EN
Published in PNAS on 9/24/2024

Absolute Metabolite Quantification in Individuals with Glioma and Healthy Individuals Using Whole-Brain Three-dimensional MR Spectroscopic and Echo-planar Time-resolved Imaging
Baboli M, Wang F, Dong Z, Dietrich J, Uhlmann EJ [et al.], Andronesi OC
Published in Radiology on 9/24/2024

SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner
Jung W, Abdelnour A, Kaplonek P, Herrero R, Shih-Lu Lee J [et al.], McNamara RP
Published in Cell Reports on 9/24/2024

Predicting Suicides Among US Army Soldiers After Leaving Active Service
Kennedy CJ, Kearns JC, Geraci JC, Gildea SM, Hwang IH [et al.], Kessler RC
Published in JAMA Psychiatry on 9/25/2024

Associations of "Weekend Warrior" Physical Activity With Incident Disease and Cardiometabolic Health
Kany S, Al-Alusi MA, Rämö JT, Pirruccello JP, Churchill TW [et al.], Khurshid S
Published in Circulation on 9/26/2024 | Press Release

AI Tool Offers More Accurate Detection of Immune-Related Adverse Events in Cancer Patients
Featuring Kerry Reynolds, MD

Mass General Brigham-led study finds large language model enhances precision and efficiency in detecting complications.

Researchers Identify Mechanism Underlying Allergic Itching, and Show It Can Be Blocked
Featuring Caroline Sokol, MD, PhD

Study led by Mass General allergy and immunology researchers may explain why some people itch more from exposure to allergens and mosquito bites, which may open new therapeutic avenues for treating allergies

Generative AI Model Study Shows No Racial or Sex Differences in Opioid Recommendations for Treating Pain
Featuring Marc Succi, MD

Large language models displaying no racial or gender discrimination have the potential of reducing bias and improving health equity in the field of pain management.

Black Women Have a Higher Risk of Dying from All Types of Breast Cancer, Meta-Analysis Reveals
Featuring Erica Warner, ScD, MPH

Findings from Mass General Brigham investigators suggest that contributing factors include socioeconomic inequality, delays in diagnosis, and inadequate access to timely quality cancer treatment

Clinical Trial Successfully Repurposes Cancer Drug for Hereditary Bleeding Disorder
Featuring Hanny Al-Samkari, MD

A clinical trial, involving researchers and patients at Mass General Hospital, found that an oral drug approved for treating a blood cancer was effective at reducing the severity of nosebleeds associated with HHT

Study of Former NFL Players Finds 1 in 3 Believe They Have CTE
Featuring Ross Zafonte, DO, Rachel Grashow, PhD, MS, & Aaron Baggish, MD

Players with concerns about CTE also report higher rates of treatable conditions that mimic CTE’s cognitive symptoms, and are more likely to be suicidal.

‘Weekend Warrior’ Physical Activity May Help Protect Against More Than 200 Diseases
Featuring Patrick Ellinor, MD, PhD and Shaan Khurshid, MD, MPH

Compared with inactivity, a weekend warrior pattern of exercise (concentrating most moderate-to-vigorous physical activity in one to two days during the week) or a more evenly distributed physical activity pattern were associated with similarly lower risks of diseases across 16 categories. The protective effects were seen in heart and digestive conditions as well as mental health and neurological illnesses. The findings indicate that concentrated physical activity patterns may be just as effective for disease prevention as patterns where exercise is spread out throughout the week.

Implementation of a Lifestyle Dementia Prevention Intervention
Featuring Ryan Andrew Mace, PhD and Ana-Maria Vranceanu, PhD

Ryan Andrew Mace, PhD, an investigator in the Center for Health Outcomes and Interdisciplinary Research (CHOIR) within the department of Psychiatry at Massachusetts General Hospital and an assistant professor of Psychology at Harvard Medical School, is the lead author of a recently published paper in the Journal of Alzheimer's Disease, “Optimizing the Implementation of a Lifestyle Dementia Prevention Intervention for Older Patients in an Academic Healthcare System”. Ana-Maria Vranceanu, PhD, is the senior author of the study.

The Public Health Impact of the FDA’s Request for Additional Safety Data on Cytisine for Tobacco Cessation
Featuring Krishna Reddy, MD, MS and Nancy Rigotti, MD

Krishna Reddy, MD, MS, a physician-investigator at the Medical Practice Evaluation Center and the Tobacco Research and Treatment Center at Massachusetts General Hospital and an Associate Professor of Medicine at Harvard Medical School, is the lead author of a new study in JAMA Health Forum, “Public Health Impact of FDA’s Request for Additional Safety Data on Cytisine for Tobacco Cessation”. Nancy Rigotti, MD, director of the Tobacco Research and Treatment Center, is senior author of the study.

Assessing the Effectiveness of Telehealth-Based Palliative Care Services for Patients with Advanced Lung Cancer
Featuring Joseph Greer, PhD, Jennifer Temel, MD and Vicki Jackson, MD, MPH

Joseph Greer, PhD, and Jennifer Temel, MD, the co-directors of the Cancer Outcomes Research and Education Program at Massachusetts General Hospital, are the lead authors of a new study in JAMA, “Telehealth Versus In-Person Early Palliative Care for Patients with Advanced Lung Cancer: A Multisite Randomized Clinical Trial”. Vicki Jackson, MD, MPH, chief of Palliative Care at Massachusetts General Hospital, is senior author of the study.

Public Health Solutions to Reduce the Impact of Pediatric Gun Violence
Featuring Eric Fleegler, MD, MPH

Eric Fleegler, MD, MPH, from the Department of Emergency Medicine at Massachusetts General Hospital and senior researcher at MGH Gun Violence Prevention Center, is the senior author of a viewpoint published in JAMA Surgery, “The Updated Haddon Matrix for Pediatric Firearm Injuries”.

Reaction Risk to Direct Penicillin
Featuring Kimberly Blumenthal, MD, MSc

Kimberly Blumenthal, MD, MSc, director of research in the Center for Drug and Vaccine Allergy at Massachusetts General Hospital and an associate professor of Medicine at Harvard Medical School, is the lead author of a review in JAMA Internal Medicine titled: “Reaction Risk to Direct Penicillin Challenges: A Systematic Review and Meta-Analysis.”

Snapshot of Science: Mass General’s High Impact Research Publications for August 2024

Individualized cancer therapy demonstrates safety and sustained immune responses, climate change’s impact on health and healthcare sustainability and much more.

World Cancer Research Day: How MGH Research Scholars are Helping to Move the Field Forward

In honor of World Cancer Research Day, we are highlighting four MGH Research Scholars whose research focuses on developing treatments and innovative solutions for patients with cancer.