Welcome to our Snapshot of Science for November 2024. Here's a quick look at some recent publications, press releases and stories about the Mass General Research Institute community.
In this issue, we highlight:
- 27 new studies published in high-impact journals
- 10 new research briefs
- 2 posts from the Mass General Research Institute blog
Empowering surgeons: will artificial intelligence change oral and maxillofacial surgery?
Sillmann YM, Monteiro JLGC, Eber P, Baggio AMP, Peacock ZS, Guastaldi FPS
Published in International Journal of Oral & Maxillofacial Surgery on 9/27/2024
Activation of STAT3-mediated ciliated cell survival protects against severe infection by respiratory syncytial virus
Zhao C, Bai Y, Wang W, Amonkar GM, Mou H [et al.], Ai X
Published in Journal of Clinical Investigation on 11/1/2024
HiDDEN: a machine learning method for detection of disease-relevant populations in case-control single-cell transcriptomics data
Goeva A, Dolan MJ, Luu J, Garcia E, Boiarsky R, Gupta RM, Macosko E
Published in Nature Communications on 11/2/2024
US Cancer Mortality Trends Among Asian and Pacific Islander Populations
Zhu DT, Pompa IR, Qi D, Goldberg SI, Lee RJ, Kamran SC
Published in JAMA Network Open on 11/4/2024
Immune responses in checkpoint myocarditis across heart, blood and tumour
Blum SM, Zlotoff DA, Smith NP, Kernin IJ, Ramesh S [et al.], Villani AC
Published in Nature on 11/6/2024 | Research Brief
Enhanced placental antibody transfer efficiency with longer interval between maternal respiratory syncytial virus vaccination and birth
Jasset OJ, Lopez Zapana PA, Bahadir Z, Shook L, Dennis M [et al.], Edlow AG
Published in American Journal of Obstetrics & Gynecology on 11/6/2024 | Research Brief
Identifying the bioimaging features of Alzheimer's disease based on pupillary light response-driven brain-wide fMRI in awake mice
Liu X, Hike D, Choi S, Man W, Ran C, Zhou XA, Jiang Y, Yu X
Published in Nature Communications on 11/7/2024
Goals of Surgical Interventions in Youths Receiving Palliative Care
Ellis DI, Chen L, Gordon Wexler S, Avery M, Kim TD [et al.], Wolfe J
Published in JAMA Network Open on 11/8/2024
Accelerometer-Measured Sedentary Behavior and Risk of Future Cardiovascular Disease
Ajufo E, Kany S, Rämö JT, Churchill TW, Guseh JS [et al.], Khurshid S
Published in Journal of American College of Cardiology on 11/11/2024 | Research Brief
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease
Serrano-Pozo A, Li H, Li Z, Muñoz-Castro C, Jaisa-Aad M [et al.], Das S
Published in Nature Neuroscience on 11/11/2024
Implantable 3D printed hydrogels with intrinsic channels for liver tissue engineering
Lieberthal TJ, Sahakyants T, Szabo-Wexler NR, Hancock MJ, Spann AP [et al.], Vacanti JP
Published in PNAS on 11/12/2024
Genetic analysis implicates ERAP1 and HLA as risk factors for severe Puumala virus infection
Haapaniemi H, Strausz S, Tervi A, Jones SE, Kanerva M; FinnGen, Estonian Biobank Research Team; [et al.], Ollila HM
Published in Human Molecular Genetics on 11/13/2024
Neural Predictors of Fear Depend on the Situation
Wang Y, Kragel PA, Satpute AB
Published in Journal of Neuroscience on 11/13/2024
Inebilizumab for Treatment of IgG4-Related Disease
Stone JH, Khosroshahi A, Zhang W, Della Torre E [et al.], Culver EL; MITIGATE Trial Investigators
Published in New England Journal of Medicine on 11/14/2024 | Research Brief
Glofitamab plus gemcitabine and oxaliplatin (GemOx) versus rituximab-GemOx for relapsed or refractory diffuse large B-cell lymphoma (STARGLO): a global phase 3, randomised, open-label trial
Abramson JS, Ku M, Hertzberg M, Huang HQ, Fox CP [et al.], Gregory GP
Published in Lancet on 11/16/2024
Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint
Tsao HW, Anderson S, Finn KJ, Perera JJ, Pass LF [et al.], Manguso RT
Published in Immunity on 11/18/2024
Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease
Hofmann A, Häsler LM, Lambert M, Kaeser SA [et al.], Schultz SA; Dominantly Inherited Alzheimer Network
Published in Nature Communications on 11/18/2024
Effect of Screening for Undiagnosed Atrial Fibrillation on Stroke Prevention
Lopes RD, Atlas SJ, Go AS, Lubitz SA, McManus DD [et al.], Singer DE
Published in Journal of American College of Cardiology on 11/19/2024
Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation
Hill MC, Simonson B, Roselli C, Xiao L, Herndon CN [et al.], Ellinor PT
Published in Nature Communications on 11/19/2024
Spatial multiomic landscape of the human placenta at molecular resolution
Ounadjela JR, Zhang K, Kobayashi-Kirschvink KJ, Jin K, J C Russell A [et al.], Shu J
Published in Nature Medicine on 11/20/2024 | Research Brief
Spatially restricted immune and microbiota-driven adaptation of the gut
Mayassi T, Li C, Segerstolpe Å, Brown EM, Weisberg R [et al.], Xavier RJ
Published in Nature on 11/20/2024
Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience
Jurgens SJ, Rämö JT, Kramarenko DR, Wijdeveld LFJM, Haas J [et al.], Bezzina CR
Published in Nature Genetics on 11/21/2024
CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual targeting antibody overcome antigen heterogeneity in AML
Silva H, Martin G, Birocchi F, Wehrli M, Kann MC [et al.], Leick MB
Published in Blood on 11/21/2024
Prenatal immune origins of brain aging differ by sex
Goldstein JM, Konishi K, Aroner S, Lee H, Remington A [et al.], Tobet SA
Published in Molecular Psychiatry on 11/21/2024 | Research Brief
Targeted Reinnervation During Gender-Affirming Mastectomy and Restoration of Sensation
Remy K, Alston C, Gonzales E, Hazewinkel MHJ, Carruthers KH [et al.], Gfrerer L
Published in JAMA Network Open on 11/22/2024
Toward Foundation Models in Radiology? Quantitative Assessment of GPT-4V's Multimodal and Multianatomic Region Capabilities
Strotzer QD, Nieberle F, Kupke LS, Napodano G, Muertz AK [et al.], Schicho A
Published in Radiology on 11/26/2024
Caenorhabditis elegans inositol hexaphosphate pathways couple to RNA interference and pathogen defense
Xu W, Sun Y, Breen P, Ruvkun G, Mao K
Published in PNAS on 11/27/2024
Researchers Develop SCOPE to Improve Early-Stage Cancer Detection
Featuring Cesar M. Castro, MD, MSc and Hakho Lee, PhD
Cesar M. Castro, MD, MSc, of the Department of Medicine and Center for Systems Biology at Massachusetts General Hospital, and Hakho Lee, PhD, of the Department of Radiology and Center for Systems Biology at Massachusetts General Hospital and the Hostetter MGH Research Scholar, are co-corresponding authors of a paper published in Nature Biotechnology, “Amplifying mutational profiling of extracellular vesicle mRNA with SCOPE.”
Study Reveals How Cancer Immunotherapy Leads to Deadly Form of Heart Inflammation in Some Patients
Featuring Alexandra-Chloé Villani, PhD, Kerry Reynolds, MD and Tomas Neilan, MD, MPH
Researchers from Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, have worked with investigators at the Broad Institute of MIT and Harvard to uncover the immune basis for checkpoint myocarditis—a dangerous form of heart inflammation that can occur as a side effect after a patient has been treated for cancer using immune checkpoint inhibitor (ICI) therapy.
Study Reveals Best Timing for Getting the RSV Vaccine During Pregnancy to Protect Newborns
Featuring Andrea Edlow, MD
Current guidelines recommend that pregnant people receive a vaccine against respiratory syncytial virus (RSV)—which typically causes mild, cold-like symptoms in most adults but can be deadly for infants—during weeks 32–36 of pregnancy. New research led by investigators at Mass General Brigham suggests that vaccination earlier in that timeframe, closer to 32 weeks, could provide the best protection for newborns against RSV.
Clinical Trial Shows Positive Results for Potential Treatment to Combat a Challenging Rare Disease
Featuring John Stone, MD, MPH
A team led by Mass General Brigham researchers demonstrated that inebilizumab reduced the risk of symptoms by 87% in patients with the rare affliction known as immunoglobulin G4–related disease (IgG4-RD)
Mass General Brigham Researchers Find Too Much Sitting Hurts the Heart
Featuring Patrick Ellinor, MD, PhD and Shaan Khurshid, MD, MPH
Investigators from Mass General Brigham, found that excessive sedentary behavior (waking activity with low energy expenditure while sitting, reclining, or lying down and not including hours spent sleeping at night) was linked to increased risk of heart disease, especially heart failure and cardiovascular death, and that these risks could be significantly reduced by substituting sedentary time for other activities.
Foralumab Nasal Spray May Offer New Hope for MS Treatment
Featuring Tanuja Chitnis, MD, FAAN
A new nasal spray treatment called foralumab may offer hope for those living with multiple sclerosis (MS). Mass General Brigham researchers recently completed a phase 1 clinical trial of foralumab, which shows promise in reducing MS symptoms and improving the quality of life for those affected by this condition.
Signals of Inflammation During Pregnancy Linked to Aging and Memory Changes 50 Years Later
Featuring Jill M. Goldstein, PhD, MPH
Findings from a Mass General Brigham-led study that has followed participants since before birth may offer clues about the origins of Alzheimer’s disease.
Multiomic Landscape of the Human Placenta at Molecular Resolution
Featuring Jian Shu, PhD
Jian Shu, PhD, an investigator in the Cutaneous Biology Research Center at Massachusetts General Hospital and an Assistant Professor of Dermatology at Harvard Medical School, is senior author of a study in Nature Medicine, "Spatial Multiomic Landscape of the Human Placenta at Molecular Resolution".
Understanding Rare Genetic Variants That Cause Diabetes
Featuring Alicia Huerta-Chagoya, PhD, Miriam Udler, PhD and Josep M Mercader. PhD
Alicia Huerta-Chagoya, PhD, Miriam Udler, PhD and Josep M Mercader. PhD, Investigators at the Diabetes Unit and Center for Genomic Medicine at Massachusetts General Hospital and at the Broad Institute of MIT and Harvard, and colleagues are lead and senior authors of a recently published paper in Nature Genetics, "Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes".
‘Alzheimer’s in Dish’ Model Shows Promise for Accelerating Drug Discovery
Featuring Doo Yeon Kim, PhD, Winston Hide, PhD, Pourya Naderi Yeganeh, PhD, Sang Su Kwak, PhD and Rudolph Tanzi, PhD
A new algorithm has determined that 3D models using mature brain cells accurately mimic the brain biology seen in human patients, allowing researchers to test multiple drugs at once and informing predictions about drug targets and therapies
About the Mass General Research Institute
Research at Massachusetts General Hospital is interwoven through more than 30 different departments, centers and institutes. Our research includes fundamental, lab-based science; clinical trials to test new drugs, devices and diagnostic tools; and community and population-based research to improve health outcomes across populations and eliminate disparities in care.
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