ω-3 PUFA for Secondary Prevention of White Matter Lesions and Neuronal Integrity Breakdown in Older Adults: A Randomized Clinical Trial
Shinto LH, Murchison CF, Silbert LC, Dodge HH, Lahna D [et al.], Bowman GL
Published in JAMA Network Open on 8/1/2024

Chimeric Antigen Receptor T Cell with an Inducible Caspase-9 Suicide Gene Eradicates Uveal Melanoma Liver Metastases via B7-H3 Targeting
Ventin M, Cattaneo G, Arya S, Jia J, Gelmi MC [et al.], Ferrone CR
Published in Clinical Cancer Research on 8/1/2024

Allysine-Targeted Molecular MRI Enables Early Prediction of Chemotherapy Response in Pancreatic Cancer
Ma H, Esfahani SA, Krishna S, Ataeinia B, Zhou IY [et al.], Caravan P
Published in Cancer Research on 8/1/2024

Decoding Patient Heterogeneity Influencing Radiation-Induced Brain Necrosis
Chamseddine I, Shah K, Lee H, Ehret F, Schuemann J [et al.], Paganetti H
Published in Clinical Cancer Research on 8/6/2024

Fully Automated Deep Learning Model to Detect Clinically Significant Prostate Cancer at MRI
Cai JC, Nakai H, Kuanar S, Froemming AT, Bolan CW [et al.], Takahashi N
Published in Radiology on 8/6/2024

The Impact of Low Workplace Support During Pregnancy on Surgeon Distress and Career Dissatisfaction
Lwin TM, Castillo-Angeles M, Cunningham CE, Atkinson RB, Kim E [et al.], Rangel EL
Published in  Annals of Surgery on 8/7/2024

Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations
Argentieri MA, Xiao S, Bennett D, Winchester L, Nevado-Holgado AJ [et al.], van Duijn CM
Published in  Nature Medicine on 8/8/2024 | Research Spotlight

Clinician Knowledge and Attitudes About Climate Change and Health After a Quality Incentive Program
Armand W, Padget M, Pinsky E, Wasfy JH, Slutzman JE, Duhaime AC
Published in  JAMA Network Open on 8/8/2024 | Press Release

T Cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination With Pembrolizumab in the Phase 1 KEYNOTE-603 Study
Gainor JF, Patel MR, Weber JS, Gutierrez M, Bauman JE [et al.], Burris HA
Published in  Cancer Discovery on 8/8/2024 | Press Release

Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation
Bell TA, Luce BE, Hakim P, Ananda VY, Dardari H [et al.], Chao LH
Published in eLife on 8/13/2024

Theta-burst direct electrical stimulation remodels human brain networks
Huang Y, Zelmann R, Hadar P, Dezha-Peralta J, Richardson RM [et al.], Paulk AC
Published in  Nature Communications on 8/14/2024

Cognitive Motor Dissociation in Disorders of Consciousness
Bodien YG, Allanson J, Cardone P, Bonhomme A, Carmona J [et al.], Schiff ND
Published in  New England Journal of Medicine on 8/14/2024

Clinical utility of a blood based assay for the detection of IDH1.R132H-mutant gliomas
Batool SM, Escobedo AK, Hsia T, Ekanayake E, Khanna SK [et al.], Carter BS
Published in  Nature Communications on 8/16/2024 | Research Spotlight

Vaginal Lactobacillus fatty acid response mechanisms reveal a metabolite-targeted strategy for bacterial vaginosis treatment
Zhu M, Frank MW, Radka CD, Jeanfavre S, Xu J [et al.], Kwon DS
Published in  Cell on 8/19/2024

Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway
Valenstein ML, Lalgudi PV, Gu X, Kedir JF, Taylor MS, Chivukula RR, Sabatini DM
Published in  PNAS on 8/20/2024

Disparities in Exposure to Tobacco on Television or Streaming Platforms
Onyeaka HK, Chido-Amajuoyi OG, Sokale I, Ajayi KV, Evins AE, Amonoo HL, Shete S
Published in  JAMA Network Open on 8/22/2024

Shared Decision-Making in Colorectal Cancer Screening for Older Adults: A Secondary Analysis of a Cluster Randomized Clinical Trial
Sepucha KR, Chang Y, Valentine KD, Atlas SJ, Han PKJ [et al.], Simmons LH
Published in  JAMA Network Open on 8/23/2024

Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases
Yuan K, Longchamps RJ, Pardiñas AF, Yu M, Chen TT [et al.], Huang H
Published in  Nature Genetics on 8/26/2024

Cryoablation and post-progression immune checkpoint inhibition in metastatic melanoma: a phase II trial
Mooradian MJ, Fintelmann FJ, LaSalle TJ, Simon J, Graur A [et al.], Sullivan RJ
Published in  Nature Communications on 8/27/2024

Label-Free Microfluidic Apheresis of Circulating Tumor Cell Clusters
Zhan L, Edd J, Mishra A, Toner M
Published in  Advanced Science on 8/28/2024

EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors
Boulay G, Broye LC, Dong R, Iyer S, Sanalkumar R [et al.], Riggi N
Published in  Nature Communications on 8/28/2024

Change in Depressive Symptoms and Longitudinal Regional Amyloid Accumulation in Unimpaired Older Adults
Munro CE, Farrell M, Hanseeuw B, Rentz DM, Buckley R [et al.], Gatchel JR
Published in  JAMA Network Open on 8/29/2024

SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner
Jung W, Abdelnour A, Kaplonek P, Herrero R, Shih-Lu Lee J [et al], McNamara RP
Published in Cell Reports on 8/29/2024

Rare coding variant analysis for human diseases across biobanks and ancestries
Jurgens SJ, Wang X, Choi SH, Weng LC, Koyama S [et al.], Ellinor PT
Published in  Nature Genetics on 8/29/2024

A conserved transcription factor regulatory program promotes tendon fate
Niu X, Melendez DL, Raj S, Cai J, Senadeera D [et al.], Galloway JL
Published in  Developmental Cell on 8/30/2024

Automated Measurement of Cerebral Hemorrhagic Contusions and Outcomes After Traumatic Brain Injury in the TRACK-TBI Study
Snider SB, Temkin NR, Sun X, Stubbs JL, [et al]., Edlow BL; TRACK-TBI Investigators
Published in  JAMA Network Open on 8/30/2024

Individualized Cancer Therapy Demonstrates Safety and Sustained Immune Responses
Featuring Justin Gainor, MD

A study led by researchers at Mass General Brigham has found that an individualized cancer therapy tailored to the unique tumor profiles of patients with melanoma and lung cancer was well-tolerated and boosted immune activity

Increasing Clinicians’ Knowledge About Climate Change’s Impact on Health and Healthcare Sustainability
Featuring Wynne Armand, MD and Ann-Christine Duhaime, MD

Physicians at an academic medical center completed surveys about climate change-focused educational modules related to health and sustainability in healthcare offered through an existing biannual quality incentive program. Most respondents thought that the modules were relevant or very relevant to their lives and clinical practices, and that their knowledge on these topics increased after completing the modules. Perceptions of the modules’ relevance varied by physicians’ demographics and specialties.

Low-dose carbon monoxide may explain the paradoxical reduced risk of Parkinson’s disease among smokers
Featuring Stephen Gomperts, MD, PhD

Smoking has consistently been associated with a reduced risk of Parkinson’s disease, raising the possibility that some factors of cigarette smoke confer protection. Researchers found that treating lab models of PD with low doses of carbon monoxide—comparable to the exposure experienced by people who smoke—protected against neurodegeneration and prevented the accumulation of a key disease-related protein. The findings support further investigation into low-dose CO and the pathways it modifies to slow disease progression in PD.

Proteomic Aging Clock Predicts Mortality and Risk of Common Age-Related Diseases in Diverse Populations
Featuring Austin Argentieri, PhD

Austin Argentieri, PhD, a research fellow in the Analytic and Translational Genetics Unit at Massachusetts General Hospital, is the lead author of a new study in Nature Medicine, “Proteomic Aging Clock Predicts Mortality and Risk of Common Age-Related Diseases in Diverse Populations”

Transforming Narratives of Gun Violence Through Community-Centered Storytelling
Featuring Peter Masiakos, MD

Peter Masiakos, MD, director of Pediatric Trauma Services at Massachusetts General Hospital, co-director of the MGH Gun Violence Prevention Center and associate professor of Surgery at Harvard Medical School, is the lead author of a recent perspective in the NEJM, “Transforming Narratives of Gun Violence”. Additional authors of this piece include Chaplain Clementina Chéry, founder, president and CEO of the Louis D. Brown Peace Institute (LDBPI), Rachele Gardner, associate director of the Engagement Lab and community organizer, and Eric Gordon, PhD, professor and Director of the Engagement Lab at Emerson College.

A Blood-Based Assay for the Detection of IDH1.R132H-Mutant Gliomas
Featuring Leonora Balaj, PhD and Bob Carter, MD

Leonora Balaj, PhD, an investigator in the department of Neurosurgery at Massachusetts General Hospital and an assistant professor of Neurosurgery at Harvard Medical School, is co-senior author of a new paper in Nature Communications, “Clinical Utility of a Blood Based Assay for the Detection of IDH1.R132H-Mutant Gliomas”. Bob Carter, MD, chair of Neurosurgery at Mass General, is co-senior author of the study. Syeda Maheen Batool, MD, an instructor in investigation in Neurosurgery at Mass General, is lead author.

Fact or Fiction? Massachusetts General Researchers Set the Record Straight on Common Food & Nutrition Misconceptions
Researchers debunk widespread misconceptions about nutrition and provide science-backed insights based on their research.

Five Things to Know: The Risk of Head and Neck Injuries from Olympic-Style Sports
Past research has shown there are short- and long-term increases in layperson sports participation coinciding with the Olympic games

Benchmarks: Mass General Research News and Notes for August 9, 2024
Study shows trust in doctors, hospitals declined during the COVID era, more info on the protective effect of aspirin in colorectal cancer & more.

Snapshot of Science: Mass General's High Impact Research Publications for July 2024
New immune cell therapy benefits laboratory models of ALS, how neurons derive meaning from spoken words and much more

Meet the Summer Research Students at Massachusetts General Hospital
Each year 1,200+ summer students come to Mass General to train in our research labs and centers. These are their stories.

Introducing the 2024 Mass General Research Institute Image Awards
Our annual contest is a chance for the Mass General research community to share their best science images and the stories behind them.